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Enzymatic demethylation of 7,8-dihydromethysticin followed by ring opening of the alpha-pyrone ring, and rearrangement was suggested to contribute to the formation of highly GSH reactive metabolite 6-phenyl-3-hexen-2-one as its mercapturic acid adduct found in human urine [43]

Instead of acting solely within mitochondria, CoQ 10 can be distributed to membranes such as the ER, plasma membrane and LDs, where its reduced form, ubiquinol, suppresses lipid peroxidation 17,22,36

Reduced glutathione is the active and most bioavailable form of glutathionea naturally occurring antioxidant found in nearly every cell of the human body

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