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Specifically, GM predominantly regulates the integrity of the intestinal barrier through its metabolites, which exert profound influences on the metabolism, proliferation, apoptosis, and genetic alterations of epithelial cells, although there are additional interactions between GM and intestinal epithelial cells that collectively contribute to the regulation of the intestinal barrier ( Figure 3 )

10.3382/ps/pez067 9

Consequently, preventing follicular atresia by inhibiting apoptosis in oocytes and granulosa cells represents a promising strategy for preserving ovarian reserve

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Bosn J Basic Med Sci 9(3):215220