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While they offer long-lasting brightening effectsoften lasting a few months to over a yearthe results fade, and the skin reverts to its original tone once treatment stops

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Glutathione peroxidase 4 (GPX4) plays a role reducing peroxidated phospholipids, preventing ferroptosis ( Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a key role in inhibiting ferroptosis by suppressing cellular iron reuptake, restricting the production of ROS, and upregulating solute carrier family 7 member 11 (SLC7A11), a cystine/glutamate antiporter ( Lipocalin-2 (LCN-2) is a glycoprotein that regulates iron homeostasis

To absorb vitamin B12, folate is needed in a trivalent form, and this dihydrofolate is converted from tetrahydrofolate by these colon bacteria with the help of the dihydrofolate reductase (DHFR) enzyme