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But it must be acknowledged that, like heavy metals, excessive concentrations of metal ions from the aforementioned metals can induce various forms of cellular damage and apoptosis, resulting in increased wound inflammation and oxidative stress responses (Song et al., 2019)

In contrast, synthetic, proliferative VSMCswhich dominate pathologies such as atherosclerosisundergo a metabolic shift toward glycolysis and possess reduced antioxidant defenses, rendering them highly vulnerable to cuproptosis [154, 155]

[DOI] [PMC free article] [PubMed] [Google Scholar] 161.George S, et al

Statistical analysis Continuous variables are expressed as means standard deviations (SDs)

doi: 10.1161/circulationaha.122.060257 35 ShahRShchepinovMSPrattDA