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It has been demonstrated that the TP53 gene, located on chromosome 17, contributes to the maintenance of mitochondrial integrity, and that TP53 deficiency can be compensated for by an increase in aerobic glycolysis and an enhancement of mitochondrial mass (42, 43)

Figure 3 5.1 Magnesium supplementation: forms, efficacy, and limitations The primary treatment for hypomagnesemia is magnesium supplementation

Jones RT

Many commercial preparations contain additional ingredients such as: Sorbitol or mannitol sugar alcohols used as sweeteners in some tablets that can cause osmotic diarrhoea when consumed in larger quantities, though the amounts in typical supplements are usually too small to cause symptoms alone [13] [14] Binding agents and fillers including lactose, which may cause symptoms in people with lactose intolerance, though tablet quantities are typically small Other additives various excipients that some individuals may be sensitive to The dose and frequency of supplementation may also influence tolerability

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