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10.1016/0033-0620(69)90038-3 59 CanoN

(2020) 52:e13824

Among them, VEGF is one of the most important angiogenic factors that regulate blood vessel formation in health and disease ( in vivo , promoting vascular wall permeability and the growth and proliferation of vascular endothelial cells and perivascular cells, the latter of which are self-renewing and regenerative ( FIGURE 1 The VEGF family of proteins includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, Placental Growth Factor (PlGF), virus-encoded VEGF-E, and the snake venom-derived VEGF-F