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Two studies [25, 27] were classified as high risk due to significant issues such as missing data and inadequate blinding (Table 2)

118 , e2105482118 (2021)

5 Additionally, central nervous system (CNS) complications are more prevalent in individuals with diabetes, with up to 50% experiencing some degree of cognitive decline

To support NOS3, we need to increase levels of BH4 by optimising production of 5-MTHF , bearing in mind this is also needed for NT synthesis and methylation