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Indeed, elevated homocysteine is now recognized as a strong risk factor for cognitive impairment and dementia, including Alzheimers disease (66-68)

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The evasion of proteasomal degradation by LD proteins likely represents an active process in regulating expression levels

found significantly decreased expression of autophagy markers, including Beclin1 and LC3, and increased p62 expression in stromal vascular fraction cells isolated from the adipose tissue of older mice (20 months) compared to that of younger mice (46 months) [84]

For dietary deficiency without neurological involvement, oral supplementation may be appropriate