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An exceptional study by Romano et al

The investigators reported that NNMT knockdown produced protection from diet-induced obesity and increased adipocyte energy expenditure, establishing the genetic precedent for the 5-Amino-1MQ pharmacological program

The same experimental design was used to show inhibition by different lipid peroxidation products (acrolein and 4-oxononenal), resulting in 60% and 100% inhibition, respectively

doi: 10.1056/NEJMra1501993 4 KreisslMCJanssenMJRNagarajahJ

In a randomized controlled trial in 64 people with a history of calcium oxalate kidney stones, three years of potassium-magnesium citrate supplementation providing about 255 mg of magnesium resulted in an 85% reduction in kidney stone risk compared with placebo (Ettinger 1997)