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Insects 3 , 10391055 (2012)

In this pathology, IGF-I levels diverge between studies, from increased to decreased IGF-I concentrations[330332], probably due to differences in samples origin (serum/cerebrospinal fluid vs spinal cord/musculoskeletal) and could be explained as a physiological defensive mechanism promoted in response to the neural degeneration and/or muscle atrophy

After batch normalization of peak intensity, a multivariate analysis was carried out using principal component analysis (PCA), partial least squares discriminant analysis (PLSDA), and orthogonal projections to latent structures discriminant analysis (OPLSDA) to identify differences between the Zn group and the control [20]