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The biosynthesis and assembly of fibrillar collagens involve a remarkable number of posttranslational modifications, including several rounds of precise proteolytic cleavage, glycosylation, catalyzed folding, and chemical cross-linking (Fig

The authors postulate that therapeutic strategies aimed at modulating glutathione levels or transporter activity might mitigate disease progression in affected individuals

In addition, mitochondrial RNA is a small RNA molecule that can alleviate mitochondrial DNA damage by breaking down the damaged mitochondrial RNA, which is also involved in the process of sperm repair of mitochondrial DNA damage

Moreover, this failure is disparately harming majority-Black, Brown, and low-income communities

doi: 10.1098/rstb.2011.0382 219 KatonaIFreundTF