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J Insect Physiol 51(10):11351147

Signalling within the cancer cells Numerous molecular pathways affecting malignant cholangiocytes have been identified, leading to the sub-classification of CCA into inflammatory or proliferative classes characterized by the induction of pro-inflammatory signals and the activation of oncogenic cascades 1,80,123

Finally, this study focused exclusively on host factors, but microbial determinants and metabolomics have also been shown to contribute to therapeutic response in IBD 49,50