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To improve predictability and discrimination among samples, OPLS-DA model was constructed using all roe samples from different families to obtain an initial comprehensive outline of compositional differences among samples, with the model accounting for 56% of the total variance

8d), including immediate early and interferon-associated genes such as JUNB , FOS , SOCS3 , APOE , IRF family members, and GADD45A/B , supporting immune-associated OL states are a conserved feature in human disease

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substantiated these findings by showing that electrophilic or oxidative activation of Nrf2 signaling pathway influenced clock gene expression and circadian rhythmicity 90