l carnitine risks L-carnitine, batch-testing, and the problem with self-prescription in elite sport. Oral L-carnitine achieves bioavailability of just 14–18% of the administered dose. In a well-nourished elite athlete with no deficiency, the evidence for Carnitine Deficiency: What Is It,

have shown that by shielding brain tissue from inflammatory reactions, taurine reduced brain damage during cerebral ischemia (118)

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Recent studies demonstrate that SCFAs affect bone metabolism via the processes outlined ( Figure 2 ): Intestinal Epithelial Function and Mineral Absorption: SCFAs act on IECs to promote their development and differentiation, hence affecting the mechanical, chemical, immune, and biological barriers of the intestinal mucosa, regulating electrolyte exchange (such as between mineral ions and hydrogen ions), lowering luminal pH, and directly improving the absorption of minerals specially calcium (99, 100);Systemic Signaling via G protein-coupled receptors (GPCRs): Upon entering systemic circulation, SCFAs interact with GPCRs, influencing metabolism and function in peripheral tissues, including adipose tissue, skeletal muscle, bone, and liver (101);Epigenetic Regulation: SCFAs block histone deacetylases (HDACs), therefore contributing to the epigenetic regulation of gene expression, which may influence bone metabolism (102, 103);Modulation of Inflammatory Cytokines: SCFAs can modulate the production of inflammatory factors, therefore affecting bone remodeling (104)

Nevertheless, larger, adequately powered randomized controlled trials are needed to confirm these findings and define optimal dosing strategies, timing of intervention, and patient subgroups most likely to benefit