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16, 17 Under conditions of BH 4 deficiency, electron flow from the reductase domain to the oxidase domain is diverted to molecular oxygen rather than to L-arginine, a substrate of NO, leading to eNOS uncoupling

Only through such efforts can we achieve the target diagnostic ensitivity/specificity of 80% essential for cost-effective, stage-specific DPN management

and whether the ammonia-rich microniches identified in hepatocellular carcinoma represent a phenomenon generalizable to other cancer types remains to be determined

GSH is synthesized via two enzymatic steps that are regulated at multiple levels

10.1016/j.celrep.2020.107538 Cell Rep