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The pharmaceutical company Allergan, owned by AbbVie, treats and purifies this botulinum toxin to create a protein that, when injected, stops muscle contractions

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Additionally, repeated intramuscular injections can cause muscle fibrosis or nerve damage if improper technique is employed

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Notably, reductions in total brain, grey and white matter volumes were observed, particularly in regions responsible for sensorimotor integration and higher-order cognition, with these changes strongly associated with chronic hyperglycaemia and glycaemic variability [30, 31]