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Genetic and organoid studies demonstrate that Desert Hedgehog and Wnt Family Member 2B (WNT2B) are also required for effective post-irradiation repair

Radiotherapy resistance represents one of the major challenges in oncology and the presence of CSCs seems to play a pivotal role in this regard [148]

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An initial study with a limited sample size (39 HAPE patients and 43 controls) revealed no role of CYBA in HAPE pathogenesis in Caucasians, 119 but a larger Indian cohort (150 HAPE patients and 180 controls) linked CYBA (rs4673 and rs9932581) and GSTP1 (rs1695 and rs1138272) to elevated circulating 8-iso-prostaglandin F2 in HAPE, potentially contributing to HAPE susceptibility