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Figure 11 Autoimmunity Upregulation of autoimmune genes As in other chronic disorders, some genes in ME/CFS patients have been found to be associated with autoimmunity, such as the HLA alleles (88), along with two other variants of HLA-DQB1 in combination with two RAGE-374A variants (489) was found

3c) is characterized by words such as abandonment, relationship, and fp (favorite person), which are central to borderline personality disorder

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We therefore propose that for a better understanding of ME/CFS, micro- and macro-circulatory failure, endothelial dysfunction, metabolic dysfunction, redox imbalance, inflammatory stimulation, and CNS inflammation need to be jointly considered (see Figure 2)