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Molecules can cross the tight junctions via two distinct size-selective and charge-selective paracellular pathways: the pore pathway and the leak pathway

The mechanism whether mediated by weight loss, direct cardiac effects, or reduced inflammation, remains an active area of preclinical and clinical investigation

But when you look at a thousand studies, and then you try it out, and then you understand some metabolic pathways, and you hypothesize, and then you test, and you look at the results, the name for that is science