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Trimethylamine -N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice

The time taken to (a) find and (b) enter the target hole was recorded, as well as the number of holes visited before the target was determined

Supraspinal neuropathological findings have been reported in patients with severe SMA, overall suggesting that the lack of SMN has widespread consequences and manifestations in the central nervous system (CNS) that are not limited to lower motor neurons (LMNs) [10,11,12]

Some patients remain asymptomatic for long time even without therapy, but are at risk of sudden death due to cardiac arrhythmia.