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CRM was also evaluated to diagnose NMSC early and the authors concluded that CRM is a promising and innovative technology for the early diagnosis of skin cancer, which may ultimately play an important role in skin cancer screening and prevention as well as in the early detection of progression or recurrence after therapy [94]

Any temperature excursion above 8C can cause irreversible protein denaturation that visual inspection wont detect

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Over time, the distribution of disease can extend or regress