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Thymosin beta-4 (the molecule behind TB-500) is best supported for central neurorestoration and remyelination : driving oligodendrocyte-progenitor differentiation and remyelination, stimulating neurogenesis and angiogenesis in injured cortex and hippocampus, and promoting neurite outgrowth in models where lesion size does not change but function still improves

Shimizu et al., 2021)

In a body-composition substudy of participants averaging about 105 kg, roughly 75% of lost weight was fat and 25% was lean

PHYSIOLOGICAL CONSEQUENCES Manipulating GH, IGF 1, inflammatory signalling, or mitochondrial pathways is not benign

These remain restricted due to stronger safety concerns or insufficient human safety data