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Larger changes (5+ letters, visual field changes exceeding test-retest variability, OCT thickness changes over 5-10 microns) more clinically relevant

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Indeed, conceptually, it would be critical to monitor the progressive pathological changes of these markers throughout adulthood, so to identify subjects possibly at risk of developing a neurodegenerative process favoured by the presence of OS induced, at least in part, by an imbalance of the KEAP1-NRF2 system