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Why Current Treatments Often Fall Short Many UC patients rely on medications such as steroids , biologics , or immunosuppressants

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This promotes the secretion of soluble chemotactic factors, such as CCL2, CCL22, CCL28, CXCL8, and CXCL12, which facilitate the recruitment of immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), M2-like TAMs, and Tregs, into the tumor 2,5