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We propose that stepwise dose titrations (e.g., 50 mg QD for 2 weeks 100 mg QD for 2 weeks 150 mg QD), based on the discretion of the treating physician, may be one approach to omaveloxolone reinitiation and may increase the possibility that patients stay on treatment in the long term

134 Mutant IDH-targeted therapy and a number of important recent pre-clinical and clinical studies in IDH-mutant solid tumors have been extensively reviewed elsewhere, 147 and listed in Table 2

Journal of the Neurological Sciences 249(1):76-85

This suggests that incorporating earlier sampling intervals may be necessary to fully capture the kinetics of ROS induction and improve the resolution of early-stage smoke-induced oxidative damage

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