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CRC cells frequently remodel their TCA cycle due to mutations (KRAS, TP53), hypoxia, or dysregulated signaling, leading to intracellular accumulation and extracellular release of specific intermediatesincluding succinate, fumarate, itaconate, and -ketoglutarate (-KG)which function as potent immunometabolites by directly modulating immune cell metabolism, epigenetic programming, and signaling pathways ( Figure 3 )

These findings might provide a reference value for the utilization of CAT as supplement for mother from late pregnancy to lactation period to promote the fatty acid metabolism of offspring

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Pregnant or nursing women, individuals with medical conditions, or those taking medications should consult a healthcare professional before use

W badaniu dotyczcym przecicia nerwu kulszowego u szczurw BPC-157 podawano po urazie w dawkach 10 g/kg lub 10 ng/kg