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In MS lesions, BDNF is primarily present in immune cells and reactive astrocytes (98), while the BDNF receptor TrkB was strongly upregulated in reactive astrocytes and in neurons in the immediate lesion vicinity (98)

Toxicity is the bigger concern, particularly if the drug has a narrow therapeutic index, where modest differences in the level can have dangerous effects

LEDs have gained more and more importance as energy-efficient plant growth light sources during the last years and have been used to study the involvement of light, with special focus on red and blue spectra, in the regulation of growth and development of the model plant Arabidopsis thaliana and various crop plants

Other representative herbal medicines with heat-clearing effect include Mori follum , Sophora japonica L., and Fallopia multiflora Herba (Vetrova et al., 2017), and Fallopia multiflora Herba ( Ephedra Herba (Saida Ibragic, 2015), Hedysarum Multijugum Maxim ( , and Plantaginis Semen ( Lycii Fructus ( Herba Taxilli (Zhu Kaixin et al., 2011), and Rubi Fructus (Zhang Jing and Yan, 2020)