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Platelets and erythrocytes were excluded from blood DE gene analysis

reported that, in SLE, IFN- or IgG can restrain GPX4 transcription through CaMKIV/CREM, which promotes an increase in the level of intracellular lipid ROS and ultimately facilitates neutrophil ferroptosis

References 1 Abd El-RadyN

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This was evidenced by the decrease in the expression of markers such as CD80, CD86, CD40, iNOS (inducible nitric oxide synthase) and MHCII (major histocompatibility complex class II), correlating with the reduction of pro-inflammatory cytokines such as IL-1 and IL-6