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Studies have demonstrated that MYC participates in various pathological aspects of RA, including synovial cell proliferation, osteoclast activation, immune inflammation, and cartilage damage

10.1016/j.reprotox.2007.07.006 Reprod

Disclosures: Liam Swain: Nothing to Disclose, Jenny Godley: Nothing to Disclose, Meng Wang: Nothing to Disclose, Jennifer Flemming: Nothing to Disclose, Mayur Brahmania: Nothing to Disclose, Juan Abraldes: Gilead: Grant/Research Support, 89bio: Consultant, Boston Pharmaceuticals: Consultant, Novo Nordisk: Consultant, Boehringer Ingelheim: Consultant, Astra Zeneca: Consultant, Agomab: Consultant, Terumo: Speaking and Teaching, Cook: Grant/Research Support, Karen Tang: Nothing to Disclose, Abdel Shaheen: Nothing to Disclose 1549 THE EFFECT OF AREA-LEVEL MATERIAL AND SOCIAL DEPRIVATION ON CIRRHOSIS AND ALCOHOL-RELATED HEPATITIS HOSPITALIZATION RATES DURING THE COVID-19 PANDEMIC: A POPULATION-BASED STUDY Liam Swain Abdel Shaheen 1 Meng Wang 2 Jennifer Flemming 3 Mayur Brahmania 1 Juan Abraldes 4 Karen Tang 1 Jenny Godley 1 , 1 University of Calgary, 2 Alberta Health Services, 3 Queen's University Cancer Research Institute, 4 University of Alberta Background: Few studies have examined the impact of the COVID-19 pandemic on hospitalization rates for alcohol-related cirrhosis/hepatitis (AC/AH) and non-alcohol-related cirrhosis (NAC) in relation to the social determinants of health

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The pharmacokinetic and pharmacodynamic profiles of two high doses of parenteral selenite in patients with systemic inflammatory response syndrome (SIRS) showed that the maximum glutathione peroxidase activity appeared only at very high dose [441]