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Additionally, interventions such as dietary fiber supplementation or probiotics ( Lactobacillus sp.) have been shown to improve cognitive function and modulate HPA axis activity (reducing cortisol response)

These found no evidence of organ toxicity, no genetic damage, and no developmental defects at doses far higher than what would be used therapeutically

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This pathway has thus been connected to both regenerative medicine, because of its role in development and tissue growth, and cancer, because of its influence on proliferation and cell survival (225, 226)

Off-label use means a doctor prescribes an FDA-approved drug for a different condition, age group, or dosage than officially approved. This is a legal and common practice