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Fertility and Sterility, 103(3), 522-528

B12 deficiency symptoms include chronic diarrhea, lethargy, weight loss, and neurological issues

Vitamin B12, also known as cobalamin, is a vital water-soluble vitamin that plays a crucial role in various bodily functions

CD38 is also one of the three ectoenzymes in the CD38/CD203a/CD73 pathway that produces ADO, which not only regulates immune response in hypoxic conditions but also suppresses the antitumor immune response by recruiting MDSCs and Treg cells, inhibiting the activity of T effector cells and thus favoring tumor progression

Liposomes bridge this gap by encapsulating the hydrophilic peptide in an aqueous core surrounded by a lipid bilayer that is compatible with the skin's sebum