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Discovery of potent poly-(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone

Its difficulties in diagnosis, high mortality rate, high recurrence rate, and poor prognosis, have always been a major obstacle for researchers

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In comparison to idiopathic PD, non-motor symptoms are less common, particularly in instances involving PRKN mutations, and neuropathological assessments often reveal a lower presence or near absence of Lewy bodies (Doherty et al