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Growth Factor Expression Upregulates TGF-b, FGF, and EGF growth factors that stimulate cell proliferation, collagen synthesis, and extracellular matrix remodeling to rebuild damaged tissue

Similarly, Dings research team engineered a system linking two shRNA transcription plasmids targeting MDR-related genes (P-glycoprotein and survivin) to doxorubicin (DOX)-loaded DNA origami via disulfide bonds [57]

Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP kinase pathway

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169 Changes in antioxidant levels and targets of oxidation have also been observed in PD, further supporting the oxidative stress involvement in the disease