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Description

When GSH, and subsequent mGSH, is low, ATP production is impaired

Figure 1A shows the results of a Western blot probed with P-gp-specific monoclonal antibody (C219) revealing the relative expression of P-gp in total cell extracts from drug sensitive Chinese hamster ovary cells (AuxB1), AuxB1 colchicine-selected drug resistant cells (CHO R C5), P-gp-knockout drug sensitive cells (AuxB1 Pgp ) and P-gp-knockout drug resistant cells (CHO R C5 PgpA1 , and CHO R C5 PgpA3 )