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P Natl Acad Sci USA 105 , 1704617049, (2008)

Nagafuchi et al., 2022)

The gcn2-atf4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

At the cellular level, 3-HK promotes apoptosis by increasing mitochondrial membrane permeability, facilitating cytochrome C release and caspase-dependent cell death accompanied by oxidative damage [139, 154]

Age-related degeneration of the vitreous body is associated with lower ascorbate levels, slower oxygen consumption and increased risk of nuclear cataract