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ATF4 resulted in the induction of heat shock protein 70 family protein 5 (HSPA5), which in turn bound GPX4 and protected against GPX4 protein degradation and subsequent lipid peroxidation (Zhu et al., 2017), and GSH-specific gamma-glutamylcyclotransferase 1 (CHAC1) degradation of GSH enhanced ferroptosis through GCN2-eIF2-ATF4-GPX4 pathway (Chen et al., 2017)

This article describes how NRF2 and other transcription factors are targets for protective phytochemicals

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Namely, proteinprotein and protein-DNA interactions are disrupted by GST tag crosslinking, which results in functional inactivation of the fused protein

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