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Patients need to be educated in proper injection techniques to prevent infection or injury and proper storage of vials to maintain drug potency

The newly updated American Diabetes Association (ADA) Standard of Care in Diabetes 2024 for Neuropathy Screening Guidelines states that patients with T2D at the time of diagnosis and those with T1D five years after diagnosis should be evaluated for DPN by obtaining a careful medical history and physical examination (sensory assessment and foot examination), and subsequently they should be evaluated every year (71)

The benzyl alcohol stops bacterial growth, which is what lets a reconstituted vial be used across multiple doses over several weeks in the fridge

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its accumulation signals that biosynthetic precursors are abundant