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Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by impaired communication and social interaction, as well as repetitive/stereotyped behaviors ( Admittedly, numerous publications have indicated that the pathogenesis of ASD was affected by immune dysregulation/inflammation, oxidative stress, and mitochondrial dysfunction ( Strikingly, existing evidence has indicated that Nrf2 plays an important role in immune dysregulation/inflammation, oxidative stress, and mitochondrial dysfunction

While former studies suggested that regressive forms of onset were not common in ASD, more recent investigations indicate that the rates are quite high and may be under-reported

These mice show both motor deficits as well as cognitive and behavioral changes i.e., pathological phenotype in the functional domains affected in cerebellar patients

It is far too preliminary to act on, but it flags gut EGT metabolism as a pathway worth watching in future risk research

doi: 10.1073/pnas.0509531103