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Description

By analyzing the properties of the targeting antibody and drug, we optimize the cleavage site and chemical structure to achieve efficient conjugation, specific cleavage, and precise drug release

Millions of patients have used tirzepatide since 2022, providing extensive real-world safety experience beyond controlled trials

22 Reduced porin expression significantly limits their uptake, which leads to resistance against these drugs

The gene coexpression network within this module revealed highly connected hub genes, with GSTU6 ( Os10g0529500 ), GSTU6 ( Os10g0527400 ), GL121 ( Os12g0154700 ), GL123 ( Os12g0154900 ), APM1 ( Os09g0362800 ), AMPL1 ( Os12g0434400 ), CAD8D ( Os09g0400400 ), C76M7 ( Os01g0561600 ), and WRKY75 ( Os11g0490900 ) likely serving as candidate hub genes that coordinates metabolic response to oxidative stress and metabolite biosynthesis (Fig