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Drug Design, Development and Therapy

doi: 10.1038/nri1352 80 KawadlerHGantzMARileyJLYangX

In the review of previous clinical and experimental studies, we find that tissues after external stimulation secrete cytokines including interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-), of which TNF- stimulates the activation of other inflammatory mediators (including NF-B), resulting in the release of inflammatory genes, and then leading to the persistence and deterioration of inflammation (Liu, 2005