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In addition to these proximal components of insulin signaling, mammalian uncoordinated-18c (Munc18-c), a protein essential for insulin-stimulated GLUT4 translocation, was reported to be O-GlcNAc modified in a background of glucosamine-induced insulin resistance, and FOXO1, a master transcriptional factor for gluconeogenic genes in liver, was also O-GlcNacylated in diabetes [77,78]

Montalban-Bravo G, Loghavi S, Li Z, Chien KS, Kanagal-Shamanna R, Bataller A, Natu A, Gurney M, Bazinet A, Hammond D, Sasaki K, Borthakur G , Swaminathan M, DiNardo CD, Kadia TM, Ravandi F, Daver NG, Short NJ, Pemmaraju N, Issa GC, Lasho TL, Finke CM, Al-Kali A, Csizmar CM, Alkhateeb HB, Gangat N, Mangaonkar AA, Bueso-Ramos CE, Tefferi A, Kantarjian HM, Garcia-Manero G, Patnaik MM

Buzzetti E, Pinzani M, Tsochatzis EA (2016) The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

The rationale is concentrating the peptide where the repair is needed

Kobatake, K