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Springer, Berlin, pp 18

& Galli, S

Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements

10.1016/j.bbrc.2015.10.056 126 LiD.ZhengJ.HuY.HouH.HaoS.LiuN.et al (2017)

For the PANSS negative score, the association between thalamic glutamate levels and negative symptoms was changed over the two years (PANSS negative*time: p = 0.003), which was due to a trend-level negative association at baseline but a significant positive association after two years (Table 3)