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In this study, we demonstrate that long-term supraphysiological range of OsG/ROS stresses disrupts the FoxO1/TXNIP pathway and results in -cell dedifferentiation, mass loss, and failure

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PMID: 3764924, DOI: 10.1016/0041-008x(86)90348-0

This is the same logic that produced CagriSema (cagrilintide + semaglutide)

doi: 10.1093/jac/37.3.617 117 FerdinandA

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