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Cell Transplant 25(5):849861 Matsuyama N, Shimizu S, Ueda K, Suzuki T, Suzuki S, Miura R, Katayama A, Ando M et al (2022) Safety and tolerability of a multilineage-differentiating stress-enduring cell-based product in neonatal hypoxic-ischaemic encephalopathy with therapeutic hypothermia (SHIELD trial): a clinical trial protocol open-label, non-randomised, dose-escalation trial

After PBS washing, images were captured using a Leica TCS SP8 Confocal laser microscope (Germany)

Acknowledgments The authors would like to thank Silvia Rodrguez for their skillful technical assistance

Additionally, human ADMSCs significantly enhanced ovarian function and follicular development in PCOS rats by modulating epigenetic modifications, such as DNA methylation and histone deacetylation, and increasing estrogen receptor expression [134]

Technically, LBNP-PC@M addresses the core limitations of current PE therapies by utilizing cell membrane hybridization to preserve key biological properties of trophoblast cells: this design not only mitigates maternal immune clearance but also significantly enhances placental accumulationproperties that could be extended to other placental disorders (e.g., fetal growth restriction, placental abruption) requiring targeted drug delivery