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[DOI] [PubMed] [PMC] Kaur J, Fahmy LM, Davoodi-Bojd E, Zhang L, Ding G, Hu J, et al

In the intestine for example, several drug metabolising enzymes are presumed to decrease the bioavailability of orally administered drugs or to activate environmental carcinogens

Scientists dont exactly know why this reaction happens but suspect that one reason is that the killed spirochetes break down and release toxins, and our immune systems response to this spill is what causes the symptoms of the Jarisch Herxheimer reaction

Impaired oral hygiene and genetic alterations resulting in susceptibility to malignancies such as Fanconi anemia have also been implicated as risk factors