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The first study was performed by Zhu et al

To characterize HCAR1 signaling pathways, a study using a cell line designed to express human HCAR1 (CHO-K1) showed activation of extracellular signal-regulated kinases (ERK1/2) via HCAR1 in response to lactate and DHBA and sensitivity to the G i protein inhibitor pertussis toxin ( i protein was central in the regulation of HCAR1-activated ERK1/2 phosphorylation via extracellular Ca 2+ , protein kinase C (PKC), and insulin-like growth factor-1 receptor (IGF-1R) activation

This shift is driven by upregulation of key glycolytic enzymes including HK2, phosphofructokinase-fructose bisphosphatase 3 (PFKFB3), and LDHA

Symptoms that arise can become the reason one seeks a prescription for an SSRI a mood booster, or for anxiety relief, or to help with sleep issues

Xia D, Zhai X, Wang H, Chen Z, Fu C, Zhu M