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Similarly, glycogen synthase kinase-3 (GSK-3) can phosphorylate specific sites on NRF2, promoting its recognition and binding by -TrCP, thereby mediating the ubiquitination and degradation of NRF2

A study of patients with pancreatic cancer and gastrointestinal tumors reported that during omega-3 supplementation prior to chemotherapy, patients gained an average of approximately 2.5 kilograms of body weight, which was maintained after chemotherapy was initiated ( 3.4 Anticancer mechanisms of phytosterols and alkaloids 3.4.1 Interference with cholesterol metabolism and tumor cell membrane structure Phytosterols such as -sitosterol are structurally similar to cholesterol and competitively interfere with cholesterol utilization by tumor cells (78)

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