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Comparison of plasma, mononuclear and polymorphonuclear leucocyte vitamin C levels in young and elderly women during depletion and supplementation

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Nrf2 is a critical factor in the cellular response to antioxidant stress, which transcriptionally activates antioxidant proteins and cytoprotective genes by binding to antioxidant response element motifs to scavenge excessive intracellular ROS and mitigate oxidative damage 31

Other studies pointed out that peptic ulcer patients display reduced plasma melatonin release (66)