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These results indicate that around 3 months, Trkb Penk -KO mutants undergo an increase in the number of TH + cells in the SNcVTA region owing to an increased level of TH expression in EBF3 + mDA neurons, which, under physiological conditions, exhibit low levels of TH or no TH

It combines the separation capabilities of high-performance liquid chromatography (HPLC) with those of a conjoined mass spectrometer 35