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A standard weight-management titration reference (based on FDA-approved Wegovy protocol): Weeks 14: 0.25 mg once weekly Weeks 58: 0.5 mg once weekly Weeks 912: 1.0 mg once weekly Weeks 1316: 1.7 mg once weekly Week 17 onward: 2.4 mg once weekly (maintenance for obesity) For T2DM glycemic control, lower maintenance doses (0.52.0 mg weekly) are used per Ozempic labeling

The authors identified future areas of investigation including male models, long-term treatment effects, and combination with other NAD+ precursors such as NMN

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Ralph Carmel reported that Black populations have significantly higher B12 levels than White populations, while we see some of the lowest levels in India and Pakistan

Get bloodwork including B12, iron, vitamin D, and a comprehensive metabolic panel every 8 to 12 weeks while on treatment